- Recapitulating the therapeutic efficacy of MSC such as repair/regeneration, immune modulation, & anti-inflammation, etc.
- Highly stable since contents are protected by lipid bilayer
- High delivery efficiency due to natural membrane structure and CD47 that functions as ‘don’t eat me’ signal to protect exosome from phagocytosis
- No toxicity
- Negligible immunogenicity
- Sterile & stringent quality control
Performs the paracrine effect* of stem cells, which are the most important substances in intercellular signaling.
The exosome ingredients are safer and more efficient since they have better physical properties than stem cell cultures or the stem cell itself.
* Paracrine effect : In the case where secreted material affects nearby cells
Mechanism of Exosome
Advantage of Exosome
safety
What is Exo-SCRT™?
EXOSOMES vs Conditioned Media (CM)
Patent lists
Cellular Uptake of ASC-exosomes
HaCaT
(Human keratinocytes)
HDF
(Human dermal fibroblasts)
(24h after ASC-exosomes treatment)
Human skin cells easily uptake ASC-exosomes, which means that stem cell-derived exosomes
Negative control
1% growth supplements
1% GS + ASCE 6 μg/ml
ASC-exosomes promote skin cell proliferation by up to 80% in a dose-dependent manner.
Enhanced Collagen Synthesis
After delivery of ASC-exosomes into fibroplasts, neocollagenesis can increase up to 6 folds.
ACS-exosomes can effectively increase the elastin amount of human dermal fibroplasts by up to 300% in vitro.
1st TEST
- Cell: HDF (Passage 8)
- Number: 2×10^5 cells / 6 well plate
- Time: 72 hr, Supernatant
- Treatment: EDB1(Negative control), PE-180181 30 μg/ml
2nd Test
- Cell: HDF (Passage 9)
- Number: 5×10^4 cells / 24 well plate
- Time: 72 h, Supernatant
- Treatment: EDB1(Negative control), PE-180181 1, 3, 10, 30, 100, 300 μg/ml
Clinical Proof-of-Concept , USA
- Aging skin: Post RF Needling
- Dull & dehydrated skin: Post Micro Needling
- Sensitive skin: Post Micro Needling
- Problem skin: Post Chemical peel
- uneven texture & enlarged pore: Post non invasive laser
Clinical Proof-of-Concept
- 1 acne patient
- 2 treatments biweekly
- Strong effectiveness for trouble skin improvement
- 2 acne patient
- 3 treatments weekly
- Strong effectiveness for trouble skin improvement
- 2 acne patient
- 3 treatments weekly
- Strong effectiveness for dry skin and pore tightening
- Erythema patient
- 68 / Male
- Long Pulse 532 Laser /GV laser (2weeks interval, 5times) + Meso Therapy(I)(3sessions 1month interval)
- Erythema relief /Skin tone and texture
- Acne/Acne scar patient
- 34/ Male
- needle RF/Secret+MTS 2mm with ASCE(5sessions in 3weeks interval)
- Acne/Acne care, Pore tightening, Skin texture
- Acne
- 39 / Female
- MTS 2mm with ASCE+ / 5session 3weeks interval
- Acne/Acne care, Pore tightening, Skin texture
- chronic inflammation skin
- 38/ Female
- Meso Therapie(I) / 5sessions 1-2weeks interval
- Inglammaion relief, Pore tightening, Skin texture
- Acne skin
- 48/Male
- needle RF/Secret with ASCE(after 3session)
- Acne/Acne care, Pore tightening, Skin texture
- 50s, Japanese patient (Instagram ID : Plumfloor27)
- 1st Tx, 1.4mm depth by a injector _ Strong effectiveness for dry skin and pore tightening
- 2nd Tx, 10mm depth by a injector _4weeks interval, Glowing effect & Lifting
